Michael Hölzel

Principal Investigator • Hölzel Lab


(0228) 287 12170


In 2003, Michael Hölzel graduated from Medical School at the Ludwig-Maximilians University (LMU) in Munich, Germany. At the same time, he worked on his MD doctorate thesis (2004) in the laboratory of Prof. Dirk Eick at the Helmholtz Zentrum München focusing on the biological functions of the c-Myc oncogene. After a residency in hematology and oncology in the medical department III (Director: Prof. Wolfgang Hiddemann) of the Klinikum Grosshadern (LMU Munich), in 2007 he moved on to become post-doctoral research fellow at the Netherlands Cancer Institute in the group of Prof. René Bernards, where he studied drug resistance mechanisms in different cancer types by genetic screening. In 2012, Michael Hölzel took a new position as a W2 professor for RNA biology the University of Bonn at the Institute of Clinical Chemistry and Clinical Pharmacology (Director: Prof. Gunther Hartmann), where he started to focus on the tumor microenvironment and cancer immunity in the framework of the Bonn cluster of excellence ImmunoSensation. Since 2019, Michael Hölzel is the director (W3 professorship) of the newly founded interdisciplinary Institute of Experimental Oncology at the University Hospital Bonn. His key research interests are i) tumor cell plasticity, inflammation and therapy resistance, ii) novel principles of adoptive cell transfer therapy and iii) deep spatial phenotyping of the human tumor microenvironment for prediction of immunotherapy responses.